Biosport Project

Bone grafts and bio-absorbable fixation systems

Activagen Injectable, Activagen Mouldable and Biocollagen Crunch are bone pastes manufactured by Bioteck (Italy).  Activagen products are made of demineralised equine cortical bone and used to stimulate the formation of new bone tissue in the treatment of contained bone defects. Biocollagen Crunch is a malleable osteoconductive bone paste formed from sponge bone granules in a collagen carrier with type I collagen from equine Achilles tendon and a Biocollagen Gel. This can be used as a carrier for autologous cell concentrates from marrow aspiration, peripheral blood and PRP.

Arthrex Quickset is an injectable resorbable calcium phosphate cement designed for filing bone voids.

Augmatrix™ Biocomposite Bone Graft by Wright Medical (USA) is licensed for orthopaedic indications in the US, including fracture repair and general bone void filling procedures. The product is an osetoconductive scaffold comprised of synthetic carbonated apatite and Bovine Type I collagen, intended for use in combination with autologous bone marrow. 

ALLOMATRIX® CUSTOM (Wright Medical, USA) is a bone Putty containing demineralized bone matrix and cancellous chips derived from the same donor. It can be combined with bone marrow aspirate or platelet concentrate.

Bilox is an FDA approved  synthetic calcium composite arthroscopic device used for interference screws in the reconstruction of anterior and posterior ligaments and suture anchors for rotator cuff repairs. It is manufactured by Biocompostites (UK).

The Biocollegan fleece is one of nine bone graft products manufactured by Bioteck (Italy). It is made from Type I collagen from equine Achilles tendon, which is used to cover grafts or for filling in defects in association with PRP and/or stem cells.

BIOCRYL® RAPIDE® Material (DePuy Synthes Mitek Sports Medicine, USA) is a second generation biocomposite material composed of 30% osteoconductive β-TCP and 70% poly-lactide co-glycolide. Mitek Sports Medicine offers a full portfolio of suture anchors and interference screws made from BIOCRYL RAPIDE Material. The material absorbs over time and allows for boney replacement at the screw site.

BIOINTRAFIX® ACL Fixation System (DePuy Synthes Mitek Sports Medicine, USA) is designed to provide soft tissue tibial fixation for ACL reconstruction. It is made from BIOCRYL® Material, a bio-absorbable, osteoconductive material.

BIORCI–HA (Smith and Nephew, UK) is a complete line of 23 bioabsorbable implants incl. technique-specific screws for ACL and PCL reconstruction.

BIOSURE interference screws - PLA-HA (Smith and Nephew, UK) combine poly-L-lactic acid (PLA) with hydroxyapatite (HA), a calcium phosphate similar to the mineral compound of bone. They are used in ACL and MPFL reconstruction. The material absorbed by the body and replaced by new bone.

Biosteon products have been on the market for over a decade, manufactured by Biocomposites (UK). This synthetic calcium composite technology is used for interference screws in the reconstruction of anterior and posterior ligaments and suture anchors for rotator cuff repairs. They provide a secure graft fixation while allowing biocompatible absorption and eventual replacement by bone.

BoneArt is a product under development by Educell (Solvenia). The company aims to develop a biological substitute for bone that will regenerate of bone tissue. The product is based on a patient’s autologous cells.

BoneSave (Stryker, USA) granules used as bone void filler. They are medical grade calcium phosphate consisting of 80% tricalcium phosphate/20% hydroxyapatite.

BoneRep™ being developed by OglioMedic (Canada) consists of injectable Calcium Phosphates combined with BMP’s, autologous bones or cells for bone growth.

Bonus II DBM is bone graft product manufactured by Biomet (Netherlands). It consists of a demineralised bone matrix containing several growth factors. It is a freeze-dried product, delivered in a syringe. The patient’s own stem cells and growth factors can be added the product before delivery (e.g. PRP or BMC aspirate). The company claim it is the "perfect balance between an autograft and an allograft".

Calcibon®, also manufactured by Biomet’s (Netherlands), is a synthetic, biodegradable, calcium phosphate based bone substitute. It is intended for filling of metaphyseal, cancellous bone defects. The chemical composition and crystalline structure of the cured material mimic the mineral part of natural bone.

chronOS™ Inject Bone Void Filler (DePuy Synthes Mitek Sports Medicine, USA) is a synthetic, osteoconductive calcium phosphate bone substitute. The material is injectable, osteoconductive, resorbable and remodeled into host bone within 6 to 18 months.

Collage by Orthofix (USA) is a synthetic bone graft substitute product. This osteoconductive scaffold in putty form is engineered to mimic the composition and pore structure of natural human bone.

DBX™ Material (DePuy Synthes Mitek Sports Medicine, USA) is an osteoinductive and osteoconductive bone graft substitute composed of demineralised bone matrix (DBM) from human donors in a sodium hyaluronate carrier. DBX Material is completely replaced by new host bone in a time ranging from 4 to 10 months.

Endobon® manufactured by Biomet (Netherlands), is a natural, osteoconductive hydroxyapatite ceramic bone graft substitute. The company claim that the interconnecting pore system of Endobon® allows the new bone to grow through the whole implant leading to a stable osseous integration into natural bone. Endobon® has been used for clinical applications for more than 10 years. It is well established as a bone substitute material for metaphyseal compression fractures.

ENGIpore bone graft by Finceramica consists of an aporous hydroxyapatite biomaterial with a structure similar to that of natural bone.  The company claim that ENGIpore rapidly absorbs bio-active proteins, growth factors and bone precursor cells contained in the physiological fluids. This encourages and begins the biological cascade leading to effective bone regeneration.

The Fresh-stored range of allografts by RTI Surgical (USA) are aimed at the sports medicine market. The company claims they allow surgeons to resurface osteochondral defects with mature hyaline cartilage and repair subchondral bone in a single procedure.

geneX is a synthetic bone graft developed by Biocomposites (UK). This is an absorbable, osteoconductive scaffold for accelerating bone growth. Although not directly marketed for the sports injury market, it could be used for treating fractures.

HydroSet (Stryker, USA) is an injectable, sculptable, and self-setting bone substitute made from osteoconductive and osteointegrative material. This calcium-phosphate cement is indicated to fill bony voids or gaps of the skeletal system (i.e., extremities, craniofacial, spine, and pelvis). converting to hydroxyapatite, the principle mineral component of bone.

MIIG® 115 Minimally-Invasive Injectable Graft (Wright Medical, USA) manufactured from the company’s alpha crystal technology is an injectable graft that hardens inside the body, completely reabsorbs and regenerate bones. It is used for treating metaphyseal defects.

MIIG® X3 High Strength Injectable Graft (Wright Medical, USA) is an injectable calcium sulfate for compression fractures that resorbs and remodels into bone.

Optecure® (Exactech, UK) is an engineered bone graft for reconstruction of the spine, pelvis and extremities.

Opteform® and Optefil® (Exactech, UK) are DBM-based allografts for a wide range of orthopaedic applications.

OpteMx® (Exactech, UK) is an engineered biomaterial that chemically and structurally mimics cancellous bone. It provides a scaffold for new bone growth.

Orthoss® by Geistlich Pharma (Switzerland) is an osteoconductive bone graft substitute material of bovine origin, for filling and reconstruction of aseptic bone defects.

Orthoss® Collagen by Geistlich Pharma (Switzerland) is a purified natural bone mineral of bovine origin combined with collagen of porcine origin, designed for orthopaedic bone regeneration.

OSferion is an osteoconductive bone graft substitute and bone void filler consisting of Beta-Tricalcium Phosphate (β-TCP) which is resorbed and replaced by bone during the healing process. Marketed by Arthrex (USA).

LifeNet Health’s (USA) Osteobiologics product range are bio-implants engineered from donated human tissue to enhance bone regeneration. The company also sell fresh osteochondral allografts for repair of articular cartilage and subchondral bone defects.

MAR0Match™ (DBM Powder) and MAR0Fuse™ (DBM Gel) by Arteriocyte (USA) are derived from a single donor and may be used in a range of orthopaedic procedures.

PHOENIX bone allografts (Tissue Bank Of France) are manufactured from femoral heads collected from living donors during hip arthroplasty surgery. Products are used for bone-void filling and reconstruction.

PRO-DENSE® Bone Graft Substitute (Wright Medical, USA) is a resorbable regenerative bone graft substitute.

PRO-STIM® (Wright Medical, USA) is an injectable Inductive Graft, composite bone graft with added DBM.

RegenOss Flexible Bone Substitute by Finceramica is a collagen-hydroxyapatite composite biomimetic scaffold for the filling of bony voids. The company claim that its unique structure and chemical composition replicate human bone and promote bone regeneration. 

OvationOS by Osiris (USA) is a bone allograft designed for the filling of bony voids and to support bone repair and regeneration. It is manufactured to preserve a structural bone matrix, osteoinductive and angiogenic growth factors and endogenous bone cells including MSCs and osteoblasts.

REGENESORB Material (Smith and Nephew, UK) is an advanced biocomposite formulation of PLGA, ß-TCP, and calcium sulfate. It is absorbed and completely replaced by bone within 24 months.

SINTlife Paste, Putty and Granules by Finceramica are synthetic fully resorbable bone grafts made of magnesium substituted hydroxyapatite nano-crystals. SINTlife grarts interact with bone-forming cells and promote deposition of new bone tissue.

SOBIO® Biphasic Bone Substitute, manufactured by Orthomed (France) is a resorbable ceramic composed of calcium phosphates: HA and ß-TCP for filling or replacement of bone defects.

TriPore from Orthogem is a resorbable ceramic bone graft which stimulates bone regeneration.


Arteriocyte (USA)

Arthrex (USA)

Biocomposites (UK)

BioMimetic (A subsidiary of Wright Medical, USA)

Bioteck (Italy)

DePuy Synthes Mitek Sports Medicine (USA)

Educell (Solvenia)

Exactech (UK)

Finceramica (Italy)

Geistlich Pharma (Switzerland)

LifeNet Health (USA)

OglioMedic (Canada)

Orthofix (USA)

Orthogem (UK)

Orthomed (France)

Osiris (USA)

RTI Surgical (USA)

Smith and Nephew (UK)

Stryker (USA)

Tissue Bank of France (France)

Wright Medical (USA)

ZimmerBiomet (Switzerland)


Data were collected via an online survey of company websites, press releases and other related documents Jan - June 2015. This information is a direct reflection of how the companies in question represent the products they sell, products in their pipeline, the therapeutic areas they are targeting and stage of development.