Biosport Project

Biological scaffolds

Alpha Chondro Shield® (ACS) (Swiss Biomed Orthopaedics) is a cell-free cartilage implant for cartilage regeneration. It relies on the migration and differentiation potential of mesenchymal progenitor cells from the subchondral bone after microfracture.

AlphaGEMS is a morselized amniotic tissue allograft which is said to provide a structural biologic matrix for wound covering and soft tissue defects. It advertised applications include a range of common sports injuries.

AlphaPATCH is a dehydrated tissue allograft derived from donor human placental tissue. It functions as a biologic scaffold to facilitate and enhance tissue regeneration and rehabilitation.

Arthrex DX Reinforcement Matrix is a porcine – derived biological scaffold used for the reinforcement and repair of soft tissues.

Biocollagen (Bioteck, Italy) is a thin biodegradable equine Achilles tendon collagen membrane that can be used as a substitute for periosteal membrane to cover grafts.

BioMatrix CRD (Arthrex, USA) is a bioresorbable device intended to be implanted at the site of an osteochondral defect in the knee or a focal articular cartilage lesion. The chondral region of the scaffold consists of bovine collagen whereas the subchondral bone region is composed of ß-Tricalciumphosphate (ß-TCP) suspended with polylactic acid (PLA). They suggest this device supports the regeneration of hyaline cartilage and subchondral bone.

BST-CarGel® (Piramal Life Sciences, Canada) is a medical device intended to promote hyaline cartilage regeneration when used in conjunction with the Bone Marrow Stimulation technique for the repair of focal articular cartilage lesions. This product recieved regulatory approval in Europe in 2012.

Chondrotissue® (BioTissue, Germany) is a 1-step, cell-free implant used to treat traumatic or degenerative cartilage defects. It relies on mesenchymal stem cells (obtained via marrow stimulating techniques) to treat damaged cartilage tissue. The scaffold used consists of two components: a polymer fleece which forms the framework structure and hyaluronic acid. This scaffold stimulates the stem cells to migrate and differentiate into new tissue.

GelrinC© (Regentis Biomaterials, USA and Israel) is a cell-free hydrogel implant that acts as a scaffold. After microfracture, the hydrogel is injected as a liquid. After exposure to UV light, the implant becomes a semi-solid and integrated with the surrounding tissue and bone. The implant degrades and is replaced by new cartilage tissue.

Bioteck (Italy) sell Heart pericardium membrane, manufactured from equine pericardium as a decellularised biological scaffold designed to reconstruct and strengthen soft tissues. Once grafted, the company claims, it acts as a matrix for fibroblast infiltration and as a substrate for the deposit of new collagen, thereby gradually degrading and being replaced by patient connective tissue.

Hyalofast™ (Anika Therapeutics, USA) is made from a semi-synthetic derivative of hyaluronic acid. It is used as a biodegradable support for the entrapment of mesenchymal stem cells to aid repair of chondral and osteochondral lesions.

Hyalonect® (Anika Therapeutics, USA) is a ‘knitted mesh’ composed of HYAFF®, a benzyl ester of hyaluronic acid. The product acts as a periosteum substitute in orthopaedic traumas and reconstruction procedures to encourage bone regeneration.

Hy-Cel Chondro-Gide® (Geistlich Pharma AG, CellMatrix, Sweden) is a resorbable biological scaffold made from porcine collagen types I and III. It is a membrane with a bilayer structure, with one compact and one porous side constructed for the treatment of articular cartilage defects.

FUSIONFLEX™ (Wright Medical, USA) is a Demineralized Moldable Scaffold that absorbs BMA, supporting bone regeneration.

GRAFTJACKET® Regenerative Tissue Matrix (Wright Medical, USA) is an acellular dermal matrix derived from human cadaveric skin. It is composed of biological substrate components including collagen types I, III, IV, and VII, elastin, chondroitin sulfate, proteoglycans, hyaluronic acid, laminin, tenacin, and fibroblast growth factor. It is used as a scaffold to reinforce soft-tissue repairs.

MaioRegen is an osteochondral substitute, marketed by Finceramica (Italy) developed from biomimetic nanotechnology. It consists of a multiphase gradient composite scaffold with the biologic and functional properties of both bone and cartilage to differentially support articular cartilage and bone regeneration. It has been developed for the treatment of osteochondral lesions.

MeRG® (Bioteck, Italy) is a 3D bioabsorbable collagen scaffold obtained from equine Achilles’ tendon that can be used in cartilage repair.

TissueMend Soft Tissue Repair Matrix (Stryker, USA) is a cellular collagen membrane used in tendon repair surgery. It serves as a scaffold for cellular ingrowth that is gradually remodeled by the body's own tissues.


Anika Therapeutics (USA)

Arthrex (USA)

Bioteck (Italy)

BioTissue (Germany)

CellMatrix (Sweden)

Finceramica (Italy)

Geistlich Pharma (Switzerland)

Piramal Life Sciences (Canada)

Stryker (USA)

Regentis Biomaterials (USA and Israel)

Wright Medical (USA)

Swiss Biomed Orthopaedics (Switzerland)


Data were collected via an online survey of company websites, press releases and other related documents Jan - June 2015. The information presented is a direct reflection of how the companies in question represent the products they sell, products in their pipeline, the therapeutic areas they are targeting and stage of development.